Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans
Selectins constitute a family of oligosaccharide binding proteins that play critical roles in regulating the trafficking of leukocytes.In T cells, L-selectin (CD62L) controls the capacity for naive and memory T cells to actively survey peripheral lymph nodes, whereas P- and E-selectin capture activated T cells on inflamed vascular endothelium to in